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Downregulation of HIF-1 is in good agreement with the lack of upregulation of glycolysis in our study but is in contrast to HIF-1 regulation reported in orbital fibroblasts, where HIF-1 protein levels and HIF signaling were both upregulated by CSE treatment [37]

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However, the CTP may reject a companys application that doesnt include animal tests and suggest testing on animals in order to get a product on the market